• Weibo Yu, Liang De Department of Spinal Surgery, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou Guangdong, 510405, P. R. China., Xiaobing Jiang, Linqiang Ye, and Zhensong Yao.
• Department of Spinal Surgery, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou Guangdong, 510405, P. R. China.
• Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Sep 8; 30 (9): 1104-1110.

ObjectiveTo compare the clinical efficacy and safety between percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fracture (OVCF) with intravertebral vacuum cleft (IVC).MethodsBetween January 2010 and December 2013, 68 patients with single OVCF and IVC were treated, and the clinical data were retrospectively analyzed. Of 68 patients, 48 underwent PVP (PVP group) and 20 underwent PKP (PKP group). There was no significant difference in age, gender, disease duration, fracture level, bone mineral density (BMD), visual analogue scale (VAS), Oswestry disability index (ODI), and preoperative radiological parameters between 2 groups (P>0.05). The intraoperative incidence of cement leakage, cement volume, and operative time were compared between 2 groups; VAS score was used for evaluation of back pain and ODI for evaluation of dysfunction; the incidence of adjacent vertebral fracture was observed within 2 years. The vertebral height and kyphotic angle were measured on X-ray films; the rate of vertebral compression (CR), reduction rate (RR), progressive height loss (PHL), reduction angle (RA), and progressive angle (PA) were calculated.ResultsThere was no significant difference in cement volume and the incidence of cement leakage between 2 groups (P>0.05). The operative time in PVP group was shorter than that in PKP group, showing significant difference (t=-8.821, P=0.000). The mean follow-up time was 2.4 years (range, 2.0-3.1 years). The VAS scores and ODI were significantly reduced at 1 day, 1 year, and 2 years after operation when compared with preoperative scores (P<0.05), but there was no significant difference between different time points after operation in 2 groups (P>0.05). Adjacent vertebral fracture occurred in 5 cases (10.4%) of PVP group and in 2 cases (10.0%) of PKP group, showing no significant difference (χ2=0.003, P=0.963). BMD was significantly increased at 1 year and 2 years after operation when compared with preoperative BMD (P<0.05), but no significant difference was found between 2 groups (t=0.463, P=0.642; t=0.465, P=0.646). The X-ray films showed that CR and kyphotic angle were significantly restored at immediate after operation in 2 groups (P<0.05); but vertebral height and kyphotic angle gradually aggravated with time, showing significant difference between at immediate and at 1 and 2 years after operation (P<0.05); there was no significant difference in CR and kyphotic angle between 2 groups at each time point (P>0.05). RR, RA, PHL, and PA showed no significant difference between 2 groups (P>0.05).ConclusionsThere is similar clinical and radiological efficacy between PVP and PKP for treatment of OVCF with IVC. Re-collapse could happen after operation, so strict observation and follow-up are needed.

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