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Anesthesia and analgesia · Oct 2019
General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in Mice.
- Mara A Serbanescu, Reilley P Mathena, Jing Xu, Tasha Santiago-Rodriguez, Theresa L Hartsell, Raul J Cano, and Cyrus D Mintz.
- From the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
- Anesth. Analg. 2019 Oct 1; 129 (4): e126e129e126-e129.
AbstractDysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing and analysis in a mouse model of general anesthesia to investigate the effects of volatile anesthetics on the diversity and composition of the intestinal microbiome. After 4-hour exposure to isoflurane, we observed a decrease in bacterial diversity. Taxonomic alterations included depletion of several commensal bacteria including Clostridiales. These data identify volatile anesthetics as potential contributors to microbial dysbiosis in the postoperative patient.
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