• Sefa Giray Batıbay, İsmail Türkmen, Sedat Duman, Savaş Çamur, Necdet Sağlam, and Sevilay Batıbay.
• Department of Orthopedics and Traumatology, Health Sciences University Ümraniye and Training and Research Hospital, İstanbul-Turkey. sefabatibay@hotmail.com.
• Ulus Travma Acil Cer. 2018 Nov 1; 24 (6): 575-580.

BackgroundThe aim of this study was to determine if the use of tranexamic acid (TXA) during intramedullary reaming treatment for tibial diaphyseal fractures was safe, reduced blood loss, or affected cost effectiveness.MethodsA total of 70 patients with a tibia diaphysis fracture were randomized into 2 groups and prospectively followed for data on blood loss, thrombosis, and fracture healing. Preoperative TXA was administered intravenously to Group A, and Group B served as the control group.ResultsWhile there was no significant difference between the preoperative and postoperative 1-hour hemoglobin (Hb) and hematocrit (Hct) levels of the patients, there was a statistically significant difference in the comparison of the postoperative 24-hour and 48-hour Hb and Hct levels. There was no need for an allogenic blood transfusion to any patient in Group A; however, 2 patients in Group B each received 1 unit of erythrocyte suspension because their Hct values dropped below 27%. There was no deep vein thrombosis or embolism observed in any of the patients.ConclusionThe application of intravenous TXA during the preoperative period in the treatment of tibial fractures with intramedullary nailing reduced the bleeding seen in the postoperative period. It did not lead to intravascular thrombosis in the postoperative period, and had no adverse effect on bone healing.

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