• Eric Deflandre, Simon Delande, Jerome Cauvain, Pierre Geradon, Anne-Francoise Donneau, Simon Lacroix, and Michel Van Dyck.
• Department of Anesthesia, Clinique Saint-Luc de Bouge, Namur, Belgium; Department of Ambulatory Surgery, Clinique Saint-Luc de Bouge, Namur, Belgium; University of Liege, Liege, Belgium; Medical ASTES, Jambes, Belgium. Electronic address: eric.deflandre@gmail.com.
• J. Cardiothorac. Vasc. Anesth. 2019 Aug 1; 33 (8): 2201-2207.

ObjectiveDelta pulse pressure and delta down are used as dynamic preload indicators of fluid responsiveness during closed chest surgery. There are few data regarding their accuracy in open chest surgery. The present study aimed to evaluate the influence of sternotomy on the accuracy of both delta pulse pressure and delta down.DesignProspective study.SettingSingle institution, nonacademic hospital.ParticipantsThe study comprised 127 adult patients scheduled for elective open chest cardiac surgery.InterventionsDelta pulse pressure and delta down were calculated for all patients before and 10 minutes after sternotomy.Measurements And Main ResultsStatistical analyses were performed to assess the influence of sternotomy on the accuracy of delta down and delta pulse pressure. Mann-Whitney and Bland-Altman analyses demonstrated a significant influence of sternotomy on delta pulse pressure values but not on delta down values. Among patients who had a positive delta down and/or delta pulse pressure before sternotomy, sternotomy significantly modified the delta pulse pressure value (p = 0.02), but not the delta down value (p = 0.22). The kappa coefficient indicated a very good agreement between delta down before and after sternotomy (0.83) and a fair agreement between delta pulse pressure before and after sternotomy (0.4). The difference between kappa coefficients was highly significant (p < 0.001).ConclusionsWithin the study population, sternotomy significantly influenced delta pulse pressure but not delta down. In this preliminary study, delta down appeared to be more accurate to evaluate fluid responsiveness during open chest surgery than did delta pulse pressure. Before promoting delta down in current practice, confirmation is needed on a larger scale.Copyright © 2018 Elsevier Inc. All rights reserved.

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