• Pain · Mar 2008

    Proinflammatory cytokines mediating burn-injury pain.

    • Gretchen J Summer, Edgar Alfonso Romero-Sandoval, Oliver Bogen, Olayinka A Dina, Sachia G Khasar, and Jon D Levine.
    • Department of Physiological Nursing, School of Nursing, University of California, C-555/P.O. Box 0440 521, Parnassus Avenue, San Francisco (UCSF), CA 94143, USA. gretchen.summer@ucsf.edu
    • Pain. 2008 Mar 1; 135 (1-2): 98-107.

    AbstractThermal burns induce pain at the site of injury, mechanical hyperalgesia, associated with a complex time-dependent inflammatory response. To determine the contribution of inflammatory mediators to burn injury-induced mechanical hyperalgesia, we measured dynamic changes in the levels of three potent hyperalgesic cytokines, interleukin IL-1 beta, IL-6, and tumor necrosis factor-alpha (TNFalpha), in skin of the rat, following a partial-thickness burn injury. Only IL-6 demonstrated a sustained increase ipsilateral but not contralateral to the burn, correlating with the prolonged ipsilateral mechanical hyperalgesia. Spinal intrathecal injection of oligodeoxynucleotides antisense for gp130, a receptor subunit shared by members of the IL-6 family of cytokines, attenuated both burn- and intradermal IL-6-induced hyperalgesia, as did intradermal injection of anti-IL-6 function blocking antibodies. These studies suggest that IL-6 is an important mediator of burn-injury pain.

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