• René Verboket, Ingo Marzi, Stefanie C Fleck, Johannes Frank, and Maren Janko.
• Department of Trauma, Hand and Reconstructive Surgery, Hospital of the Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
• Eur J Trauma Emerg Surg. 2020 Jun 1; 46 (3): 635-640.

ObjectiveIn acute and chronic infections of soft tissue, a radical surgical debridement is necessary, and is regarded as the 'Gold Standard, as well as an immediately systemic antibiotic therapy. Additional treatment with local antibiotics and/or antibiotic-containing materials is commonly used in clinical settings, but the efficient concentration of the antibiotic is not well-known.MethodsAside from the typical procedures which are provided and supported by the industry, we have conducted an animal study including 39 Sprague Dawley rats. We have treated the back sores with local antibiotics (vancomycin) alone or in two combinations with a fibrin-glue spray technique.ResultsIt could be demonstrated that, in particular, the simultaneous application of vancomycin and fibrin leads to a stable antibiotic concentration and a long period of time wherein the antibiotic substance remains in the tissue.ConclusionsThis easy and inexpensive method of application can be a promising factor for the clinical improvement of local antibiotic therapy.

19 keywords...

hide…