• Don Hayes, Kevin C Wilson, Katelyn Krivchenia, Hawkins Stephen M M SMM, Ian M Balfour-Lynn, David Gozal, Howard B Panitch, Mark L Splaingard, Lawrence M Rhein, Geoffrey Kurland, Steven H Abman, Timothy M Hoffman, Christopher L Carroll, Mary E Cataletto, Dmitry Tumin, Eyal Oren, Richard J Martin, Joyce Baker, Gregory R Porta, Deborah Kaley, Ann Gettys, and Robin R Deterding.
• Am. J. Respir. Crit. Care Med. 2019 Feb 1; 199 (3): e5-e23.

BackgroundHome oxygen therapy is often required in children with chronic respiratory conditions. This document provides an evidence-based clinical practice guideline on the implementation, monitoring, and discontinuation of home oxygen therapy for the pediatric population.MethodsA multidisciplinary panel identified pertinent questions regarding home oxygen therapy in children, conducted systematic reviews of the relevant literature, and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach to rate the quality of evidence and strength of clinical recommendations.ResultsAfter considering the panel's confidence in the estimated effects, the balance of desirable (benefits) and undesirable (harms and burdens) consequences of treatment, patient values and preferences, cost, and feasibility, recommendations were developed for or against home oxygen therapy specific to pediatric lung and pulmonary vascular diseases.ConclusionsAlthough home oxygen therapy is commonly required in the care of children, there is a striking lack of empirical evidence regarding implementation, monitoring, and discontinuation of supplemental oxygen therapy. The panel formulated and provided the rationale for clinical recommendations for home oxygen therapy based on scant empirical evidence, expert opinion, and clinical experience to aid clinicians in the management of these complex pediatric patients and identified important areas for future research.

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