• Sudarshini Ramanathan, Kristina Prelog, Elizabeth H Barnes, Esther M Tantsis, Stephen W Reddel, Andrew P D Henderson, Steve Vucic, Mark P Gorman, Leslie A Benson, Gulay Alper, Catherine J Riney, Michael Barnett, John D E Parratt, Todd A Hardy, Richard J Leventer, Vera Merheb, Margherita Nosadini, Victor S C Fung, Fabienne Brilot, and Russell C Dale.
• Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia/Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia.
• Mult. Scler. 2016 Apr 1; 22 (4): 470-82.

BackgroundRecognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes.ObjectiveWe aimed to define radiological features of first-episode demyelinating ON.MethodsWe performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON (n=7).ResultsBilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal involvement was more common in AQP4-ON (5% vs. 64% vs. 15%), and bilateral optic tract involvement was more common in AQP4-ON (0% vs. 45% vs. 0%). Retrobulbar involvement was more common in MOG-ON, whereas intracranial involvement was more common in AQP4-ON. MOG-ON and AQP4-ON had longer lesion lengths than MS-ON. The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. AQP4-ON more frequently had severe and sustained visual impairment.ConclusionMOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway.© The Author(s), 2015.

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