• J Neuroimaging · Mar 2019

    Clinical, Sonographic, and Electrophysiologic Longitudinal Features of Chronic Inflammatory Demyelinating Polyneuropathy.

    • Anna Lena Fisse, Kalliopi Pitarokoili, Nadine Trampe, Jeremias Motte, Antonios Kerasnoudis, Ralf Gold, and Min-Suk Yoon.
    • Department of Neurology, Ruhr University Bochum, Bochum, Germany.
    • J Neuroimaging. 2019 Mar 1; 29 (2): 223-232.

    Background And PurposeSeveral studies have aimed to find potential biomarkers to simplify the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) and to monitor and predict the disease course. However, reliable markers are still lacking. We aimed to investigate whether high-resolution nerve ultrasound (HRUS) is suitable for monitoring the long-term clinical course of CIDP.MethodsTwenty patients fulfilling the definite diagnostic criteria of CIDP received clinical examination, evaluation of the INCAT (inflammatory neuropathy cause and treatment) overall disability sum score (ODSS) as well as nerve conduction studies, and HRUS every 6 months over a median follow-up time of 34 months. Patients were divided into clinically stable/regressive disease course or progressive disease course according to the development of the ODSS.ResultsThe intranerve cross-sectional-area (CSA) variability of the nerves of the lower extremity increased with disease progression, whereas it remained unchanged in patients with a stable or remitting disease course.ConclusionNerve ultrasound can be used as a method to objectify the long-term disease course in CIDP patients. The intranerve CSA variability is suitable for monitoring the clinical course of patients with CIDP.© 2018 by the American Society of Neuroimaging.

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