• The lancet oncology · Jan 2019

    Review Practice Guideline

    Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium.

    • Eva Clemens, Marry M van den Heuvel-Eibrink, Renée L Mulder, KremerLeontien C MLCMPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Melissa M Hudson, Roderick Skinner, Louis S Constine, Johnnie K Bass, Claudia E Kuehni, Thorsten Langer, Elvira C van Dalen, Edith Bardi, Nicolas-Xavier Bonne, Penelope R Brock, Beth Brooks, Bruce Carleton, Eric Caron, Kay W Chang, Karen Johnston, Kristin Knight, Paul C Nathan, Etan Orgel, Pinki K Prasad, Jan Rottenberg, Katrin Scheinemann, Andrica C H de Vries, Thomas Walwyn, Annette Weiss, Antoinette Am Zehnhoff-Dinnesen, Richard J Cohn, Wendy Landier, and International Guideline Harmonization Group ototoxicity group.
    • Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.
    • Lancet Oncol. 2019 Jan 1; 20 (1): e29e41e29-e41.

    AbstractChildhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity (hearing loss, tinnitus, or both). To ensure optimal care and reduce consequent problems-such as speech and language, social-emotional development, and learning difficulties-for these CAYA cancer survivors, clinical practice guidelines for monitoring ototoxicity are essential. The implementation of surveillance across clinical settings is hindered by differences in definitions of hearing loss, recommendations for surveillance modalities, and remediation. To address these deficiencies, the International Guideline Harmonization Group organised an international multidisciplinary panel, including 32 experts from ten countries, to evaluate the quality of evidence for ototoxicity following platinum-based chemotherapy and head or brain radiotherapy, and formulate and harmonise ototoxicity surveillance recommendations for CAYA cancer survivors.Copyright © 2019 Elsevier Ltd. All rights reserved.

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