• Journal of critical care · Jun 2019

    Case Reports

    Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report.

    • Francesco Marrazzo, Grant Larson, Tenzing T Sherpa Lama, Maddalena Teggia Droghi, Maurice Joyce, Fumito Ichinose, Michael T Watkins, Christopher Stowell, Jerome Crowley, and Lorenzo Berra.
    • Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: FMARRAZZO@MGH.HARVARD.EDU.
    • J Crit Care. 2019 Jun 1; 51: 213216213-216.

    AbstractHemoglobin-based oxygen carriers (HBOCs) are used in extreme circumstances to increase hemoglobin concentration and improve oxygen delivery when allogenic red blood cell transfusions are contraindicated or not immediately available. However, HBOC-induced severe pulmonary and systemic vasoconstriction due to peripheral nitric oxide (NO) scavenging has stalled its implementation in clinical practice. We present a case of an 87 year-old patient with acute life-threatening anemia who received HBOC while breathing NO gas. This case shows that inhaled NO allows for the safe use of HBOC infusion by preventing HBOC-induced pulmonary and systemic vasoconstriction.Copyright © 2018 Elsevier Inc. All rights reserved.

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