• Tomohiro Kawasaki, Kazuhiro Miwa, Jun Shinoda, Yoshitaka Asano, Hiroaki Takei, Yuka Ikegame, Kazutoshi Yokoyama, Hirohito Yano, and Toru Iwama.
• Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo, Gifu, Japan; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan. Electronic address: t2111006@edu.gifu-u.ac.jp.
• World Neurosurg. 2019 May 1; 125: 93-100.

AbstractThe aims of the present study were to compare the longitudinal changes of glioblastoma multiforme after radiotherapy (RT) between 11C-methionine positron emission tomography (MET-PET) and gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) and to clarify whether these changes were predictive of survival. We included 30 patients, who had undergone MET-PET and Gd-MRI before and every 3 months after RT. The lesion/normal brain uptake (L/N) ratio and contrast-enhancing lesion volume were examined. The L/N ratio was decreased until 9 months after RT with significance until 3 months. The contrast-enhancing lesion volume was decreased until 3 months and thereafter increased until 9 months with significance. The variation rates of the L/N ratio between pre-RT and 3 months differentiated survival of >23 months from ≤23 months. A dissociation could exist in the longitudinal changes of GBM after RT between MET-PET and Gd-MRI. The variation rate of the L/N ratio could be related to survival.Copyright © 2019 Elsevier Inc. All rights reserved.

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