• Jeremiah S Hinson, Nour Al Jalbout, Michael R Ehmann, and Eili Y Klein.
• Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address: hinson@jhmi.edu.
• J Crit Care. 2019 Jun 1; 51: 111-116.

PurposeTo determine the risk for acute kidney injury (AKI) attributable to intravenous contrast media (CM) administration in septic patients.Materials And MethodsThis was a single-center retrospective propensity matched cohort analysis performed in the emergency department (ED) of an academic medical center. All visits for patients ≥18 years who met sepsis diagnostic criteria and had serum creatinine (SCr) measured both on arrival to the ED and again 48 to 72 h later were included. Of 4171 visits, 1464 patients underwent contrast-enhanced CT (CECT), 976 underwent unenhanced CT and 1731 underwent no CT at all.ResultsThe primary outcome was incidence of AKI. Logistic regression and between-groups odds ratios with and without propensity-score matching were used to test for an independent association between CM administration and AKI. Incidence of AKI was 7.2%, 9.4% and 9.7% in those who underwent CECT, unenhanced CT and no CT. CM administration was not associated with increased incidence of AKI.ConclusionsSepsis is a medical emergency proven to benefit from early diagnosis and rapid initiation of treatment, which is often aided by CECT. Our findings argue against withholding CM for fear of precipitating AKI in potentially septic patients.Copyright © 2019 Elsevier Inc. All rights reserved.

26 keywords...

hide…