• Ryosuke Takegawa, Daijiro Kabata, Kentaro Shimizu, Saya Hisano, Hiroshi Ogura, Ayumi Shintani, and Takeshi Shimazu.
• Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: r-takegawa@hp-emerg.med.osaka-u.ac.jp.
• J Crit Care. 2019 Jun 1; 51: 139-144.

PurposeThe aim of this study was to evaluate an association between nutritional biomarkers and prognosis in septic patients.MethodsWe retrospectively searched the association between nutritional biomarkers including serum albumin (Alb), total protein (TP), total cholesterol (T-chol), and cholinesterase (ChE), and prognosis for septic patients treated in the ICU for >7 days. We used time-dependent Cox proportional hazard regression analysis to resolve the difference of the statistical weight of each day's data for all 14 consecutive days among individual sepsis patients. The covariates were based on the minimum moving values determined from 1 day, 3 days, 7 days, and 14 days of serial data. The values of these covariates and ICU survival were considered as outcomes.ResultsWe included 136 septic patients. The decreases in the values of Alb, TP, T-chol, and ChE were significantly associated with the risk of death in the septic patients (p < .05). Especially, the daily changes of Alb were significantly associated with mortality during the ICU stay (p < .05).ConclusionsWe found that the changes in serial data of the nutritional markers of Alb, TP, T-chol, and ChE reflected the higher risk of death in patients with prolonged sepsis.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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