• Sean Pirkle, Samuel Kaskovich, David J Cook, Alisha Ho, Lewis L Shi, and Michael J Lee.
• Department of Orthopaedic Surgery and Rehabilitation Medicine, University of Chicago Medical Center, Chicago, IL.
• Spine. 2019 Mar 15; 44 (6): 384-388.

Study DesignA retrospective database review.ObjectiveThe purpose of this study was to analyze the rate of nonunion in patients treated with structural allograft and intervertebral cages in anterior cervical discectomy and fusion (ACDF).Summary Of Background DataExisting literature consists primarily of single-center studies with inconsistent findings.MethodsWe performed a retrospective analysis of 6130 patients registered in the PearlDiver national database through Humana Insurance from 2007 to 2016. All ACDF patients with anterior plating who were active in the database for at least 1 year were included in the study. Patients with a fracture history within 1 year of intervention, past arthrodesis of hand, foot, or ankle, or a planned posterior approach were excluded from the study. Patients were stratified by number of levels treated, tobacco use, and diabetic condition. Nonunion rates of structural allograft and intervertebral cage groups after 1 year were compared using Chi-squared analyses.ResultsFour thousand sixty-three patients were included in the allograft group, while 2067 were included in the cage group. Overall nonunion rates were significantly higher in the cage group (5.32%) than in allograft group (1.97%) (P < 0.01). When controlling for confounders, increased rates of nonunion were consistently observed in the cage group, achieving statistical significance in 25 of the 26 analyses.ConclusionThe increased rate of nonunion associated with intervertebral cages may suggest the superiority of allograft over cages in ACDF.Level Of Evidence3.

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