• Zhenlei Liu, Wanru Duan, Hao Wu, Xingwen Wang, Yu Qian, Kai Wang, Jian Guan, Fengzeng Jian, and Zan Chen.
• Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
• Spine. 2019 Jul 15; 44 (14): 975-981.

Study DesignA mechanism-based reasoning and retrospective cohort study.ObjectiveTo establish a quantitative relationship between the change of clivo-axial angle (CXA) and the change of subaxial cervical lordosis (CL) in correction surgery of atlantoaxial dislocation (AAD).Summary Of Background DataThe evolving understanding of mechanism has dramatically improved the treatment modality of AAD. Cervical sagittal alignment is another important aspect of the surgery, in addition to reduction of odontoid process. However, a quantitative reference for correction surgery has not been established.MethodsFrankfort-axial angle (FXA) was introduced. Based on two assumptions, (1) sagittal alignment of the spine aims at keeping horizontal gaze and (2) deformities at craniovertebral junction make little impact on slope of T1 vertebra, we deduced that the change of CXA equaled change of CL (ΔCXA = -ΔCL). We retrospectively reviewed our case cohort to validate this finding with linear regression analysis.ResultsSixteen cases (eight male and eight female, mean age 40.4±12.5 yr old) were included. Liner fitting equation for ΔFXA and ΔCXA is y=1.005x (coefficient of determination, R=0.966; significance of the estimated coefficients P<0.001, t-statistics) and that for ΔCL and ΔCXA is y=-1.023x (R=0.976, P<0.001). These results support our deduction that ΔCXA = -ΔCL, which can be used as a guidance of quantitative correction of sagittal deformity in AAD.ConclusionCorrection of CXA will influence the subaxial cervical lordosis (ΔCXA = -ΔCL) of AAD patients. This equation can serve as a quantitative reference for preoperative planning and intraoperative refining of the correction of cervical sagittal deformity in AAD.Level Of Evidence4.

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