• Anaesthesia · Aug 2018

    Review

    Sodium-glucose co-transporter type-2 inhibitors: pharmacology and peri-operative considerations.

    • D A Milder, T Y Milder, and Kam P C A PCA University of Sydney, Royal Prince Alfred Hospital, Camperdown, NSW, Australia..
    • Concord Repatriation Hospital, Hospital Road, Concord, NSW, Australia.
    • Anaesthesia. 2018 Aug 1; 73 (8): 1008-1018.

    AbstractSodium-glucose co-transporter 2 (SGLT2) inhibitors are an emerging class of oral hypoglycaemic agents with therapeutic benefits beyond better glycaemic control. A major concern of the sodium-glucose co-transporter 2 inhibitors is their propensity to cause euglycaemic ketoacidosis in the peri-operative period and the potential for this critical diagnosis to be delayed or missed entirely. This review attempts to collate the case reports of sodium-glucose co-transporter 2 inhibitor ketoacidosis associated with surgery to highlight and put a perspective on this peri-operative issue. Preventive strategies and the management of the ketoacidosis are discussed.© 2018 The Association of Anaesthetists of Great Britain and Ireland.

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