• Fabricio Tavares Mendonça, Lucas Macedo da Graça Medeiros de Queiroz, Cristina Carvalho Rolim Guimarães, and Alexandre Cordeiro Duarte Xavier.
• Centro de Ensino e Treinamento do Hospital de Base do Distrito Federal, Unidade de Anestesiologia e Medicina Perioperatória, Brasília, DF, Brazil. Electronic address: fabricio.tavares@me.com.
• Braz J Anesthesiol. 2017 Jan 1; 67 (1): 50-56.

Background And ObjectivesHemodynamic response to airway stimuli is a common phenomenon and its management is important to reduce the systemic repercussions. The objective of this study is to compare the efficacy of intravenous magnesium sulfate versus lidocaine on this reflex hemodynamics after laryngoscopy and tracheal intubation.MethodsThis single-center, prospective, double-blind, randomized study evaluated 56 patients ASA 1 or 2, aged 18-65 years, scheduled for elective surgeries under general anesthesia with intubation. The patients were allocated into two groups: Group F received 30mg·kg-1 of magnesium sulphate and Group L, 2mg·kg-1 of lidocaine, continuous infusion, immediately before the anesthetic induction. Blood pressure (BP), heart rate (HR), and bispectral index (BIS) were measured in both groups at six different times related to administration of the study drugs.ResultsIn both groups there was an increase in HR and BP after laryngoscopy and intubation, compared to baseline. Group M showed statistically significant increase in the values of systolic and diastolic blood pressure after intubation, which was clinically unimportant. There was no difference in the BIS values between groups. Among patients receiving magnesium sulfate, three (12%) had high blood pressure versus only one among those receiving lidocaine (4%), with no statistical difference.ConclusionMagnesium sulfate and lidocaine have good efficacy and safety for hemodynamic management in laryngoscopy and intubation.Copyright © 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

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