• Hela G Zouari, Abir Wahab, Ng Wing Tin Sophie S EA 4391, Faculty of Medicine, Paris-Est-Creteil University, Créteil, France. Physio, Damien Sène, and Jean-Pascal Lefaucheur.
• EA 4391, Faculty of Medicine, Paris-Est-Creteil University, Créteil, France.
• Pain Pract. 2019 Apr 1; 19 (4): 426-434.

ObjectiveWe attempted to determine whether clinical features could differentiate painful small-fiber neuropathy related to primary Sj€ogren's syndrome (pSS-SFN) from idiopathic SFN (idio-SFN).MethodsValidated clinical questionnaires and neurophysiological investigations specific for pain and SFN assessment were performed in 25 patients with pSS-SFN and 25 patients with idio-SFN.ResultsPatients with idio-SFN had more frequent severe burning sensations and higher mean anxiety scores and daily pain intensity compared to patients with pSSSFN. Conversely, patients with pSS-SFN had reduced electrochemical skin conductance measured by Sudoscan_, and almost half of them had the sensation of walking on cotton wool.ConclusionOur results suggest that idio-SFN more specifically involved small sensory fibers than pSS-SFN, in which subtle dysfunction of larger sensory fibers and damage of distal autonomic sudomotor innervation may occur. A practical algorithm is proposed to help to differentiate SFN associated with pSS from idio-SFN, based on information very easy to obtain by clinical interview.© 2019 World Institute of Pain.

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