• Joan M Raurich, Juan A Llompart-Pou, Mariana A Novo, Cristina Talavera, Mireia Ferreruela, and Ignacio Ayestarán.
• Servei de Medicina Intensiva, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain. Electronic address: joan.raurich@ssib.es.
• J Crit Care. 2018 Jun 1; 45: 144-148.

PurposeTo identify risk factors of successful continuous renal replacement therapy (CRRT) weaning and to evaluate the effect of furosemide in the recovery of urine output after CRRT stop.Materials And MethodsRetrospective, observational study of critical patients treated with CRRT. Weaning tests (WT) were classified in two groups: successful (urine output was recovered and CRRT was not required again) and failed (CRRT was required again). A multiple logistic regression model was used to identify risk factors of successful CRRT WT. The prediction ability was assessed with the area under the receiver operating characteristic curves (AUC-ROC).ResultsEighty-six patients underwent 101 CRRT WT. The multivariate model identified that the risk factors of successful CRRT weaning were sex and 6h-urine output after CRRT stop. The AUC-ROC was 0.81 (0.72-0.90) for 6h-urine output before and 0.91 (0.84-0.96) for 6h-urine output after CRRT stop. The AUC-ROC for 6h-urine output after WT to predict successful CRRT weaning were 0.94 (0.88-1.0) in patients who received furosemide and 0.85 (0.72-0.99) in patients who did not.ConclusionsUrine output after CRRT stop was the main risk factor of successful CRRT weaning. Administration of furosemide increased the strength of this association.Copyright © 2018 Elsevier Inc. All rights reserved.

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