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Nature neuroscience · Jul 2010
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.
- Maile R Brown, Jack Kronengold, Valeswara-Rao Gazula, Yi Chen, John G Strumbos, Fred J Sigworth, Dhasakumar Navaratnam, and Leonard K Kaczmarek.
- Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.
- Nat. Neurosci. 2010 Jul 1; 13 (7): 819-21.
AbstractIn humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.
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