• David J DiBenedetto, Kelly M Wawrzyniak, Matthew Finkelman, Ronald J Kulich, Lucy Chen, Michael E Schatman, Melissa T Stone, and Jianren Mao.
• Boston Pain Care, Waltham, Massachusetts.
• Pain Med. 2019 Nov 1; 20 (11): 2155-2165.

ObjectiveTo determine the relationship between opioid dose change, pain severity, and function in patients with chronic pain.DesignRetrospective cohort study.SettingCommunity interdisciplinary pain management practice.SubjectsA total of 778 patients with chronic pain prescribed opioids for three or more consecutive months between April 1, 2013, and March 1, 2015.MethodsChanges in opioid dose, pain severity rating, modified Roland Morris Disability Questionnaire score, and opioid risk data were extracted from medical records and analyzed for associations.ResultsTwo hundred forty-three subjects (31.2%) had an overall dose decrease, 223 (28.7%) had a dose increase, and 312 (40.1%) had no significant change in dose (<20% change). There was a weak negative correlation between change in opioid dose and change in pain severity (r = -0.08, P = 0.04) but no association between change in disability scores and dose change (N = 526, P = 0.13). There was a weak positive correlation between change in pain severity rating and change in disability scores (r = 0.16, P < 0.001).ConclusionsThe results suggest that escalating opioid doses may not necessarily result in clinically significant improvement of pain or disability. Similarly, significant opioid dose reductions may not necessarily result in worsened pain or disability. This exploratory investigation raised questions of possible subgroups of patients who might demonstrate improvement of pain and disability with opioid dose adjustments, and further research should prospectively explore this potential, given the limitations inherent in retrospective analyses. Prescribers should still consider reduction of opioid doses as recommended by current guidelines, in an effort to mitigate the potential risks associated with high-dose treatment.© 2019 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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