• Evangelia Kararizou, Evangelos Anagnostou, George P Paraskevas, Sofia D Vassilopoulou, Dimitrios Naoumis, Grigoris Kararizos, and Konstantinos Spengos.
• Department of Neurology, Athens National University, Eginition Hospital, 72-74 Vas.Sofias av., 11528 Athens, Greece. ekarariz@med.uoa.gr
• J Headache Pain. 2011 Aug 1; 12 (4): 489-91.

AbstractHeadache related to airplane flights is rare. We describe a 37-year-old female patient with multiple intense, jabbing headache episodes over the last 3 years that occur exclusively during airplane flights. The pain manifests during take-off and landing, and is located always in the left retro-orbital and frontotemporal area. It is occasionally accompanied by dizziness, but no additional symptoms occur. Pain intensity diminishes and disappears after 15-20 min. Apart from occasional dizziness, no other symptoms occur. The patient has a history of tension-type headache and polycystic ovaries. Blood tests and imaging revealed no abnormalities. Here, we present the first case in Greece. We review the current literature on this rare syndrome and discuss on possible pathophysiology and the investigation of possible co-factors such as anxiety and depression.

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