• Endocrinol. Metab. Clin. North Am. · Mar 2011

    Review

    The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors.

    • Ben Lawrence, Bjorn I Gustafsson, Mark Kidd, Marianne Pavel, Bernhard Svejda, and Irvin M Modlin.
    • Gastrointestinal Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, 310 Cedar Street, PO Box 208602, New Haven, CT 06520-8062, USA.
    • Endocrinol. Metab. Clin. North Am. 2011 Mar 1; 40 (1): 111-34, viii.

    AbstractChromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs). The value of the chromogranin A lies in its universal cosecretion by the majority of neuroendocrine cells that persists after malignant transformation. Clinicians aware of the physiologic role of chromogranin A and its secretion in a variety of non-NET-related pathologic conditions can use this protein as a moderately effective tumor biomarker in the management of GEP-NETs.Copyright © 2011 Elsevier Inc. All rights reserved.

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