• Karim Bouattour, Jean-Louis Teboul, Laurent Varin, Eric Vicaut, and Jacques Duranteau.
• From the University Hospitals of Paris-Sud, Assistance Publique Des Hôpitaux De Paris, Critical Care and Anesthesia Department, Antoine Béclère Hospital, Clamart, France (K.B.) University Hospitals of Paris-Sud, Assistance Publique Des Hôpitaux De Paris, Medical Intensive Care Unit (J.-L.T.) Critical Care and Anesthesia Department (L.V., J.D.), Bicêtre Hospital, Le Kremlin Bicêtre, France Clinical Research Unit, UMR 942, Lariboisiere University Hospital, Paris, France (E.V.).
• Anesthesiology. 2019 Apr 1; 130 (4): 541-549.

BackgroundDynamic indices, such as pulse pressure variation, detect preload dependence and are used to predict fluid responsiveness. The behavior of sublingual microcirculation during preload dependence is unknown during major abdominal surgery. The purpose of this study was to test the hypothesis that during abdominal surgery, microvascular perfusion is impaired during preload dependence and recovers after fluid administration.MethodsThis prospective observational study included patients having major abdominal surgery. Pulse pressure variation was used to identify preload dependence. A fluid challenge was performed when pulse pressure variation was greater than 13%. Macrocirculation variables (mean arterial pressure, heart rate, stroke volume index, and pulse pressure variation) and sublingual microcirculation variables (perfused vessel density, microvascular flow index, proportion of perfused vessels, and flow heterogeneity index) were recorded every 10 min.ResultsIn 17 patients, who contributed 32 preload dependence episodes, the occurrence of preload dependence during major abdominal surgery was associated with a decrease in mean arterial pressure (72 ± 9 vs. 83 ± 15 mmHg [mean ± SD]; P = 0.016) and stroke volume index (36 ± 8 vs. 43 ± 8 ml/m; P < 0.001) with a concomitant decrease in microvascular flow index (median [interquartile range], 2.33 [1.81, 2.75] vs. 2.84 [2.56, 2.88]; P = 0.009) and perfused vessel density (14.9 [12.0, 16.4] vs. 16.1 mm/mm [14.7, 21.4], P = 0.009), while heterogeneity index was increased from 0.2 (0.2, 0.4) to 0.5 (0.4, 0.7; P = 0.001). After fluid challenge, all microvascular parameters and the stroke volume index improved, while mean arterial pressure and heart rate remained unchanged.ConclusionsPreload dependence was associated with reduced sublingual microcirculation during major abdominal surgery. Fluid administration successfully restored microvascular perfusion.

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