• Eur J Anaesthesiol · May 2019

    Multicenter Study Observational Study

    Genetics and postsurgical neuropathic pain: An ancillary study of a multicentre survey.

    • Pierre Blanc, Emmanuelle Génin, Béline Jesson, Claude Dubray, Christian Dualé, and EDONIS-gene Investigating group.
    • From the AP-HP, Génétique médicale, Hôpital Necker-Enfants Malades (PB), INSERM, UMR1163, Paris (PB), INSERM, UMR1078 (EG), CHU Brest, EFS (EG), Université de Brest, Brest (EG), HELIXIO, Groupe Hybrigenics, Saint-Beauzire (BJ), CHU Clermont-Ferrand, Centre de Pharmacologie Clinique (C. Dubray, C. Dualé), INSERM, CIC1405 & UMR1107 (C. Dubray, C. Dualé), Université Clermont Auvergne, Clermont-Ferrand, France (C. Dubray).
    • Eur J Anaesthesiol. 2019 May 1; 36 (5): 342-350.

    BackgroundNeuropathic pain following surgery could be a useful model for the study of the genetic mechanisms of peripheral neuropathic pain.ObjectiveThe aim of this study was to identify genetic predictors of persistent postsurgical neuropathic pain.DesignAn ancillary study from a prospective cohort.SettingEighteen French university hospitals.PatientsFive hundred and sixty-one patients at risk of persistent postoperative pain who underwent scheduled surgery were classified as 159 cases and 402 controls.InterventionPre-operative blood sampling for DNA analysis and questionnaires sent at the third and sixth month after surgery.Main Outcome MeasuresThe phenotype was the report of pain at the site of surgery with a positive response in the DN4 questionnaire within 6 months after surgery. Out of a list of 126 candidate genes involved in the initial processes of peripheral neuropathic pain, a set of 4599 single nucleotide polymorphisms was tested on an Illumina chip. We carried out the association tests, based on an additive model, on 4422 single nucleotide polymorphisms.ResultsAfter correcting for type-I error inflation, only one suggestive association was reached for one single nucleotide polymorphism, the rs2286614, which we had selected to tag KCNK4. This gene encodes for TRAAK, a two-pore domain background K channel involved in the modulation of the primary thermoreceptors of the transient receptor potential channels family.ConclusionThis is the first genetic association study specifically investigating the occurrence of persistent postsurgical neuropathic pain. Its results help target future research to better understand the mechanisms of peripheral neuropathic pain.Trial RegistrationClinicalTrials.gov (ref. NCT00812734).

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