• Manuel F Granja, Guilherme Jose Agnoletto, Andre Monteiro, Alejandra Jaume, Mark Hanly, Esther Bit-Ivan, Mohammad Chmayssani, Eric Sauvageau, Amin Aghaebrahim, and Ricardo A Hanel.
• Lyerly Neurosurgery/Baptist Neurological Institute, Jacksonville, Florida, USA.
• World Neurosurg. 2019 Jul 1; 127: 121-125.

BackgroundA cardiac myxoma (CM) is the most common primary tumor of the heart. This case report highlights that for metastatic CMs, even after a successful total resection, there is a small but real risk of recurrence that can manifest as late as 10 years after initial tumor resection.Case DescriptionWe present the case of a 53-year-old woman who visited the emergency room after a 4-day worsening right-sided weakness. The patient was diagnosed with a left CM 10 years previously, and a complete surgical resection was performed at that time. A noncontrast computed tomography of the head revealed a left parietal hematoma and a contrast computed tomography scan of the head revealed an enlarged left parieto-occipital vein that was subsequently shown to be part of an arteriovenous fistula. After embolization of the fistula was performed, postprocedure magnetic resonance imaging of the brain showed redemonstration of acute intraparenchymal hemorrhage with vasogenic edema. The history of a previously resected CM and the multifocal distribution of brain lesions opened the possibility of slow-growing metastasis from the previous myxoma.ConclusionsOur case report demonstrates the metastatic nature of CMs to the central nervous system, even after successful gross total resection and no local relapsing mass in subsequent ultrasonographic follow-ups. A comprehensive evaluation on clinical and imagological grounds is mandatory to rule out the presence of myxomatous metastatic disease. Awareness and recognition of the potential neurologic manifestations of a metastatic CM will prevent unnecessary diagnostic workup and treatments.Copyright © 2019 Elsevier Inc. All rights reserved.

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