• Mult. Scler. · Feb 2017

    Case Reports

    Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence.

    • Frédéric Bacchetta, Amandine Mathias, Myriam Schluep, and Renaud Du Pasquier.
    • Laboratory of Neuroimmunology, Service of Neurology, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland.
    • Mult. Scler. 2017 Feb 1; 23 (2): 300-303.

    BackgroundNatalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML).ObjectiveWe describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1.ConclusionThe clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.

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