• Keng-Liang Kuo, Chih-Lung Lin, Chieh-Hsin Wu, Chih-Hui Chang, Hung-Pei Tsai, Joon-Khim Loh, Ann-Shung Lieu, and Yu-Feng Su.
• Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
• World Neurosurg. 2019 Jul 1; 127: e311-e320.

BackgroundPrimary melanocytic neoplasms (PMNs) are rare neoplasms, especially within the central nervous system. Meningeal melanocytomas, a subtype of PMN, are even rarer. Nevus of Ota results from the incomplete migration of melanocytes from the neural crest. Synchronous nevus of Ota and meningeal melanocytoma are infrequently encountered in clinical practice.ObjectiveTo evaluate and elucidate 12 cases of synchronous meningeal melanocytoma and nevus of Ota, thereby improving the understanding of the relationship between these 2 diseases.MethodsWe reviewed cases and searched the English-language literature from the PubMed database and collected clinical parameters of 12 cases of synchronously occurring nevus of Ota and meningeal melanocytoma.ResultsAmong the 12 cases, 90.90% and 91.66% of the lesions were located ipsilaterally and supratentorially, respectively.ConclusionsOur findings indicated a trend for both types of lesion to be located ipsilaterally and supratentorially. When a patient with nevus of Ota is found to harbor an intracranial neoplasm, the most likely diagnosis is PMN.Copyright © 2019 Elsevier Inc. All rights reserved.

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