• Rev Hosp Clin Fac Med Sao Paulo · May 2000

    Neuromuscular blockade in children.

    • J F Almeida, W J Kalil Filho , and E J Troster.
    • Department of Pediatrics, Hospital das Clínicas, Faculty of Medicine, University of São Paulo.
    • Rev Hosp Clin Fac Med Sao Paulo. 2000 May 1; 55 (3): 105-10.

    AbstractNeuromuscular blocking agents (NMBAs) have been widely used to control patients who need to be immobilized for some kind of medical intervention, such as an invasive procedure or synchronism with mechanical ventilation. The purpose of this monograph is to review the pharmacology of the NMBAs, to compare the main differences between the neuromuscular junction in neonates, infants, toddlers and adults, and moreover to discuss their indications in critically ill pediatric patients. Continuous improvement of knowledge about NMBAs pharmacology, adverse effects, and the many other remaining unanswered questions about neuromuscular junction and neuromuscular blockade in children is essential for the correct use of these drugs. Therefore, the indication of these agents in pediatrics is determined with extreme judiciousness. Computerized (Medline 1990-2000) and active search of articles were the mechanisms used in this review.

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