• Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew, Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group, and Neurologic Outcomes Research Group (NORG).
• From the Department of Anesthesiology (R.Y.K., T.B., M.B., N.T., M.F.N., J.P.M.), Department of Radiology (O.G.J., S.B.-N.), Department of Biostatistics and Bioinformatics (Y.-J.L., W.Q.), and the Department of Psychiatry and Behavioral Science (P.M.D.), Duke University, Durham, North Carolina. University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Mayo Clinic, Rochester University of California, Berkeley University of Pennsylvania University of Southern California University of California, Davis Brigham and Women's Hospital/Harvard Medical School Indiana University Washington University St. Louis University of Pennsylvania Prevent Alzheimer's Disease 2020 (Chair) Siemens Alzheimer's Association University of Pittsburgh Washington University St. Louis Cornell University Albert Einstein College of Medicine of Yeshiva University AD Drug Discovery Foundation Acumen Pharmaceuticals Washington University St. Louis Northwestern University National Institute of Mental Health Brown University Eli Lilly (Chair) BWH/HMS (Chair) University of Washington (Chair) Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, Davis (Core Principal Investigator) University of California, Davis University of California, San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester University of London University of California, Los Angeles School of Medicine University of California, San Francisco Magnetic Resonance Imaging University of California, Davis Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic University of California, Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute University of Pittsburgh University of California, Berkeley Washington University St. Louis Washington University St. Louis Washington University St. Louis Washington University St. Louis (ASCP) - Past Investigator University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco University of California, San Diego Prevent Alzheimer's Disease 2020 University of California, San Diego National Institute on Aging University of California, San Francisco Brown University National Institute of Mental Health Cornell University Johns Hopkins University Richard Frank Consulting Prevent Alzheimer's Disease 2020 National Institute on Aging Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University University of Southern California University of Southern California University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of Michigan University of Michigan Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham Mount Sinai School of Medicine Mount Sinai School of Medicine Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Johns Hopkins University Johns Hopkins University Johns Hopkins University Johns Hopkins University New York University New York University New York University New York University Duke University Medical Center Duke University Medical Center Duke University Medical Center University of Pennsylvania University of Pennsylvania University of Pennsylvania University of Pennsylvania University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Pittsburgh University of Pittsburgh University of Pittsburgh University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine University of Texas Southwestern Medical School University of Texas Southwestern Medical School University of Texas Southwestern Medical School Emory University Emory University Emory University University of Kansas, Medical Center University of Kansas, Medical Center University of Kansas, Medical Center University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Indiana University Indiana University Indiana University Indiana University Indiana University Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cleveland Clinic Lou Ruvo Center for Brain Health Cleveland Clinic Lou Ruvo Center for Brain Health Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Premiere Research Inst (Palm Beach Neurology) Premiere Research Inst (Palm Beach Neurology) Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Stanford University Stanford University Stanford University Stanford University Stanford University Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Boston University Boston University Boston University Boston University Boston University Howard University Howard University Howard University Case Western Reserve University Case Western Reserve University Case Western Reserve University Case Western Reserve University University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento Neurological Care of CNY Parkwood Hospital Parkwood Hospital Parkwood Hospital University of Wisconsin University of Wisconsin University of Wisconsin University of California, Irvine - BIC University of California, Irvine - BIC University of California, Irvine - BIC Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Dent Neurologic Institute Dent Neurologic Institute Dent Neurologic Institute Ohio State University Ohio State University Ohio State University Albany Medical College Albany Medical College Albany Medical College Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Rhode Island Hospital Rhode Island Hospital Rhode Island Hospital Butler Hospital Butler Hospital Butler Hospital UC San Francisco UC San Francisco UC San Francisco Medical University South Carolina Medical University South Carolina Medical University South Carolina St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care Nathan Kline Institute Nathan Kline Institute Nathan Kline Institute University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine Cornell University Cornell University Cornell University Cornell University University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Brigham and Women's Hospital/ Harvard Medical School University of California, Davis Mayo Clinic, Rochester University of California, Berkeley Washington University St. Louis Indiana University Perelman School of Medicine, University of Pennsylvania University of Southern California Perelman School of Medicine, University of Pennsylvania University of California, San Francisco Rehabilitation Institute of Chicago, Feinberg School of Medicine, Northwestern University University of Washington (Chair) Core Principal Investigator Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Francisco University of California, San Francisco University of California, San Francisco Neylan Davis (Core Principal Investigator) Neylan San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Senjem Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute Senjem Berkeley Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco Department of Defense (retired) University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Rush University Medical Center Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Duke University Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine Medical University South Carolina Medical University South Carolina Medical University South Carolina Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) University of California, San Francisco University of California, San Francisco University of California, San Francisco University of California, San Francisco Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Howard University Howard University Howard University University of Wisconsin University of Wisconsin University of Wisconsin University of Washington University of Washington University of Washington Stanford University Stanford University Stanford University Stanford University Cornell University Cornell University Cornell University.
• Anesthesiology. 2018 Apr 1; 128 (4): 728744728-744.

BackgroundAmyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively.MethodsAmyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9). The association of 6-week amyloid deposition with cognitive dysfunction was assessed by multivariable regression, accounting for age, years of education, and baseline cognition. Differences between the surgical cohort with cognitive deficit and the Alzheimer's Disease Neuroimaging Initiative cohorts (normal and early/late mild cognitive impairment) was assessed, adjusting for age, education, and apolipoprotein E4 genotype.ResultsThe authors found that 6-week abnormal global cortical amyloid deposition was not associated with cognitive dysfunction (13 of 37, 35%) at 6 weeks postoperatively (median standard uptake value ratio [interquartile range]: cognitive dysfunction 0.92 [0.89 to 1.07] vs. 0.98 [0.93 to 1.05]; P = 0.455). In post hoc analyses, global cortical amyloid was also not associated with cognitive dysfunction at 1 or 3 yr postoperatively. Amyloid deposition at 6 weeks in the surgical cohort was not different from that in normal Alzheimer's Disease Neuroimaging Initiative subjects, but increased over 1 yr in many areas at a rate greater than in controls.ConclusionsIn this study, postoperative cognitive dysfunction was not associated with 6-week cortical amyloid deposition. The relationship between cognitive dysfunction and regional amyloid burden and the rate of postoperative amyloid deposition merit further investigation.

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