• Hirotaka Hasegawa, Masahiro Shin, Taichi Kin, and Nobuhito Saito.
• Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan. Electronic address: hirohasegawa-tky@umin.ac.jp.
• World Neurosurg. 2019 Jun 1; 126: 484-490.

Backgroundvon Hippel-Lindau disease-related hemangioblastoma is likely to occur in the cerebellum and accompany a cyst. As multiple hemangioblastomas commonly occur in von Hippel-Lindau disease, and multiple surgeries may thus be necessary, a minimally invasive surgical strategy is of great importance.MethodsWe present 2 patients with von Hippel-Lindau disease-related hemangioblastomas successfully treated by a fully endoscopic transcranial approach via a short skin incision and a 2 cm × 2 cm small bony window. Before surgery, a three-dimensional virtual reality model was created to determine the ideal trajectory.ResultsPatient 1 had 2 serial large cystic tumors that equally contributed to obstructive hydrocephalus and were resected sequentially via a single endoscopic trajectory. Patient 2 had a progressive large cystic tumor that was resected endoscopically. Complete resection of the tumors was achieved without any complications in either patient.ConclusionsSmall nodular tumors accompanying a large cyst are plausible candidates for endoscopic transcranial surgery. The spatial relationship of nodules, cyst, and cerebellar parenchyma is important to determine the applicability of the present technique. Preoperative three-dimensional virtual reality simulation helps assess the feasibility of this approach.Copyright © 2019 Elsevier Inc. All rights reserved.

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