• Antimicrob. Agents Chemother. · Aug 2004

    Clinical Trial

    Pharmacokinetics of intravenous itraconazole in stable hemodialysis patients.

    • John F Mohr, Kevin W Finkel, John H Rex, Jose R Rodriguez, Gerhard J Leitz, and Luis Ostrosky-Zeichner.
    • Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens, University of Texas Health Science Center, Houston, Texas 77030, USA. john.mohr@uth.tmc.edu
    • Antimicrob. Agents Chemother. 2004 Aug 1; 48 (8): 3151-3.

    AbstractThe pharmacokinetics of intravenous itraconazole (ITC) was studied in dialysis patients. Dialysis had no effect on the half-life and clearance of ITC or OH-ITC. However, dialysis allowed the clearance of hydroxypropyl-beta-cyclodextrin (HP-beta-CD). The area under the concentration-time curve from time zero to infinity (AUC(0- infinity)) for HP-beta-CD administered before dialysis was lower than the AUC(0- infinity) when it was administered after dialysis (P < 0.01). Administration of ITC intravenously just prior to hemodialysis appears to produce adequate systemic exposures of ITC and OH-ITC while allowing dialysis clearance of HP-beta-CD. Studies of multiple administrations are warranted.

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