• Anita Gupta, Karin S Coyne, Catherine Datto, and Christine Venuti.
• Liechtenstein Institute Fellow, Princeton University, Woodrow Wilson School of Public and International Affairs, Princeton, New Jersey, USA.
• Pain Med. 2018 Dec 1; 19 (12): 2459-2468.

ObjectiveThe purpose of this analysis was to evaluate the experience of opioid-induced constipation in younger patients and identify differences in the experience of opioid-induced constipation and its symptoms between younger patients (<50 years) and older patients (50-64 years).DesignPost hoc analysis of data from a 24-week prospective, multinational, longitudinal observational cohort study (NCT01928953).SettingOutpatient clinics in the United States, Canada, Germany, and United Kingdom.SubjectsTwo age-based subgroups of adult patients with chronic noncancer pain receiving four or more weeks of daily opioid therapy and experiencing opioid-induced constipation within the previous two weeks.MethodsThe number of spontaneous bowel movements, frequency of constipation symptoms, amount of bother associated with symptoms, Patient Assessment of Constipation-Symptoms questionnaire, and health-related quality of life and function outcomes.ResultsOverall, 419 patients were included in this analysis (younger patients, N = 184; older patients, N = 235). Among younger and older patients, respectively, constipation occurred within the first week after initiating opioid therapy for 32.8% and 35.9%. At baseline, the mean numbers of spontaneous bowel movements/week were 1.3 and 1.5, and moderate opioid-induced constipation-related interference with pain management was reported by 46.6% and 44.5%. Younger patients generally reported that opioid-induced constipation symptoms were more bothersome than did older patients. The impact of opioid-induced constipation on health-related quality of life, work productivity, and day-to-day activities was comparable.ConclusionsIn these patients receiving opioid therapy for chronic noncancer pain, the burden of opioid-induced constipation was comparable or greater for patients aged <50 years compared with that for patients aged 50-64 years.

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