• Alejandro A Diaz, Linfu Zhou, Tom P Young, Merry-Lynn McDonald, Rola Harmouche, James C Ross, San Jose Estepar Raul R Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Emiel F M Wouters, Harvey O Coxson, William MacNee, Stephen Rennard, François Maltais, Gregory L Kinney, John E Hokanson, George R Washko, and ECLIPSE investigators.
• Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115. Electronic address: ADiaz6@Partners.org.
• Acad Radiol. 2014 Oct 1; 21 (10): 1255-61.

Rationale And ObjectivesComputed tomography (CT) of the chest can be used to assess pectoralis muscle area (PMA) and subcutaneous adipose tissue (SAT) area. Adipose tissue content is associated with inflammatory mediators in chronic obstructive pulmonary disease (COPD) subjects. Based on gender differences in body composition, we aimed to assess the hypothesis that in subjects with COPD, the relationships between PMA, SAT, and blood biomarkers of inflammation differ by gender.Materials And MethodsWe compared chest CT measures of PMA and SAT on a single slice at aortic arch and supraesternal notch levels from 73 subjects (28 women) with COPD between genders. The relationships of PMA and SAT area to biomarkers were assessed using within-gender regression models.ResultsWomen had a lesser PMA and a greater SAT area than men (difference range for PMA, 13.3-22.8 cm²; for SAT, 11.8-12.4 cm²; P < .05 for all comparisons) at both anatomic levels. These differences in PMA and SAT remained significant after adjustment for age and body mass index. Within-gender regression models adjusted for age showed that SAT was directly associated with C-reactive protein (for aortic arch level, P = .04) and fibrinogen (for both anatomic locations, P = .003) only in women, whereas PMA was not associated with any biomarkers in either gender.ConclusionsIt appears that in subjects with COPD, there are gender-based differences in the relationships between subcutaneous adipose tissue and inflammatory biomarkers.Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

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