• Anesthesiology · Sep 2019

    Review

    Imaging the Injured Lung: Mechanisms of Action and Clinical Use.

    • Maurizio Cereda, Yi Xin, Alberto Goffi, Jacob Herrmann, David W Kaczka, Brian P Kavanagh, Gaetano Perchiazzi, Takeshi Yoshida, and Rahim R Rizi.
    • From the Department of Anesthesiology and Critical Care and the Department of Radiology (M.C., Y.X., R.R.R.), University of Pennsylvania, Philadelphia, Pennsylvania the Interdepartmental Division of Critical Care Medicine and Department of Medicine (A.G.) Hospital for Sick Children (B.P.K., T.Y.), University of Toronto, Toronto, Ontario, Canada the Departments of Anesthesia and Biomedical Engineering (J.H.) Anesthesia, Radiology, and Biomedical Engineering (D.W.K.), University of Iowa, Iowa City, Iowa the Hedenstierna Laboratory and Uppsala University Hospital, Uppsala University, Uppsala, Sweden (G.P.).
    • Anesthesiology. 2019 Sep 1; 131 (3): 716749716-749.

    AbstractAcute respiratory distress syndrome (ARDS) consists of acute hypoxemic respiratory failure characterized by massive and heterogeneously distributed loss of lung aeration caused by diffuse inflammation and edema present in interstitial and alveolar spaces. It is defined by consensus criteria, which include diffuse infiltrates on chest imaging-either plain radiography or computed tomography. This review will summarize how imaging sciences can inform modern respiratory management of ARDS and continue to increase the understanding of the acutely injured lung. This review also describes newer imaging methodologies that are likely to inform future clinical decision-making and potentially improve outcome. For each imaging modality, this review systematically describes the underlying principles, technology involved, measurements obtained, insights gained by the technique, emerging approaches, limitations, and future developments. Finally, integrated approaches are considered whereby multimodal imaging may impact management of ARDS.

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