• Antimicrob. Agents Chemother. · Sep 2014

    In vitro efficacy of brincidofovir against variola virus.

    • Victoria A Olson, Scott K Smith, Scott Foster, Yu Li, E Randall Lanier, Irina Gates, Lawrence C Trost, and Inger K Damon.
    • Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Poxvirus and Rabies Branch, Atlanta, Georgia, USA.
    • Antimicrob. Agents Chemother. 2014 Sep 1; 58 (9): 5570-1.

    AbstractBrincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using "the Animal Rule," established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models. Compared to cidofovir, brincidofovir has increased potency, is administered orally, and shows no evidence of nephrotoxicity. Here we report that the brincidofovir half-maximal effective concentration (EC50) against five variola virus strains in vitro averaged 0.11 μM and that brincidofovir was therefore nearly 100-fold more potent than cidofovir. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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