• Headache · Feb 2013

    Review

    Human studies in the pathophysiology of migraine: genetics and functional neuroimaging.

    • Cutrer F Michael FM Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. and Jonathan H Smith.
    • Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
    • Headache. 2013 Feb 1; 53 (2): 401-12.

    AbstractThe expansion of technologies available for the study of migraine pathophysiology has evolved greatly over the last 15 years. Two areas of rapid progress are investigations focusing on the genetics of migraine and others utilizing novel functional neuroimaging techniques. Genetic studies are increasingly focusing on sporadic migraine and the utilization of unbiased searches of the human genome to identify novel variants associated with disease susceptibility. At the same time, neuroimaging studies have provided novel insights into the altered neuronal and network dynamics of the migrainous brain. These 2 parallel approaches provide complementary insights into the complexity and heterogeneity of migraine.© 2012 American Headache Society.

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