• Trends Pharmacol. Sci. · Oct 2015

    Review

    Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

    • Takashi Angata, Corwin M Nycholat, and Matthew S Macauley.
    • Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
    • Trends Pharmacol. Sci. 2015 Oct 1; 36 (10): 645-660.

    AbstractThe sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based therapies are in clinical trials and continue to be developed for the treatment of lymphoma/leukemia and autoimmune disease, while the therapeutic potential of glycan-based strategies for cargo delivery and immunomodulation is a promising new approach. Here we review these strategies with special emphasis on emerging approaches and disease areas that may benefit from targeting the Siglec family. Copyright © 2015 Elsevier Ltd. All rights reserved.

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