• Pain · May 2019

    Review

    Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain.

    • Diane Reckziegel, Etienne Vachon-Presseau, Bogdan Petre, Thomas J Schnitzer, Marwan N Baliki, and A Vania Apkarian.
    • Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
    • Pain. 2019 May 1; 160 Suppl 1: S37-S48.

    AbstractThis review expounds on types and properties of biomarkers for chronic pain, given a mechanistic model of processes underlying development of chronic pain. It covers advances in the field of developing biomarkers for chronic pain, while outlining the general principles of categorizing types of biomarkers driven by specific hypotheses regarding underlying mechanisms. Within this theoretical construct, example biomarkers are described and their properties expounded. We conclude that the field is advancing in important directions and the developed biomarkers have the potential of impacting both the science and the clinical practice regarding chronic pain.

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