• Georgios Orfanos, Justin Lim, and Bishoy Youssef.
• Trauma and Orthopaedics, University Hospitals of North Midlands NHS Trust, Royal Stoke Hospital, Newcastle Road, Stoke-on-Trent, ST4 6QG, UK. g.orfanos@nhs.net.
• Arch Orthop Trauma Surg. 2019 Apr 1; 139 (4): 475-482.

BackgroundThe increasing demand for arthroplasty has resulted in an inevitable rise in the number of periprosthetic fractures around implants. Survival factors looking into patient's comorbidities and how they influence outcome are rare. This study aims to identify correlations between survival post-injury and pre-existing comorbidities.MethodsA total of 144 patients underwent operative treatment for either a hip or a knee periprosthetic fracture from January 2008 to August 2017 at our Major Trauma Hospital. The mean age at injury was 80.9 years old (SD 9.9). Each patient had a case-based analysis to ascertain injury characteristics, operative parameters and comorbidities.ResultsThe mean survival was 12.7 months (95% CI 8.4-17.1). Survival analysis showed a correlation between age more than 75 years old (p = 0.001), ASA grade of 3 or higher (p = 0.009 Breslow's test), history of CVA or TIA (p = 0.038 Breslow's test), dementia (p = 0.002 log rank test), depression (p = 0.013 log rank test) and gender (p = 0.041, Breslow's test) and survival post-periprosthetic fracture. Survival within the first year following injury was found to be affected by the presence of osteoporosis (p = 0.020) and dementia (p = 0.002).ConclusionPeriprosthetic fractures are associated with a high mortality risk (34.7%). Operative risks can be minimised with careful optimisation and surgical planning. ASA, age and comorbidities (dementia, CVA or TIA, osteoporosis) have a significant correlation with survival post-injury. Hence, careful patient selection for operative treatment is advised.

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