• Clin. Pharmacol. Ther. · Jan 2010

    Comparative Study

    Comparison of critical drug-drug interaction listings: the Department of Veterans Affairs medical system and standard reference compendia.

    • E L Olvey, S Clauschee, and D C Malone.
    • Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
    • Clin. Pharmacol. Ther. 2010 Jan 1; 87 (1): 48-51.

    AbstractThe objective of this study was to evaluate the agreement among the US Department of Veterans Affairs (VA) listing of "critical" drug-drug interactions (DDIs) and two standard drug-interaction compendia. A list of critical DDIs, as defined by the VA, was compared with two standard commercially available compendia (Micromedex DRUG-REAX and Drug Interactions: Analysis and Management (DIAM)) in order to determine the level of agreement among the systems. Of 982 DDIs classified as critical by the VA, only 136 DDIs (13.7%) were considered critical in all three systems. Our conclusion was that, overall, there is poor agreement among the compendia and the VA system.

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