• P M Hopkins, P J Cooke, R C Clarke, A B Guttormsen, P R Platt, P Dewachter, D G Ebo, T Garcez, L H Garvey, D L Hepner, D A Khan, H Kolawole, P Kopac, M Krøigaard, J J Laguna, S D Marshall, P M Mertes, M A Rose, V Sabato, L C Savic, S Savic, T Takazawa, G W Volcheck, S Voltolini, and Sadleir P H M PHM Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; Anaesthetic Allergy Referral Centre of Western Austral.
• Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Anaesthetic Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address: p.m.hopkins@leeds.ac.uk.
• Br J Anaesth. 2019 Jul 1; 123 (1): e29-e37.

BackgroundGrading schemes for severity of suspected allergic reactions have been applied to the perioperative setting, but there is no scoring system that estimates the likelihood that the reaction is an immediate hypersensitivity reaction. Such a score would be useful in evaluating current and proposed tests for the diagnosis of suspected perioperative immediate hypersensitivity reactions and culprit agents.MethodsWe conducted a Delphi consensus process involving a panel of 25 international multidisciplinary experts in suspected perioperative allergy. Items were ranked according to appropriateness (on a scale of 1-9) and consensus, which informed development of a clinical scoring system. The scoring system was assessed by comparing scores generated for a series of clinical scenarios against ratings of panel members. Supplementary scores for mast cell tryptase were generated.ResultsTwo rounds of the Delphi process achieved stopping criteria for all statements. From an initial 60 statements, 43 were rated appropriate (median score 7 or more) and met agreement criteria (disagreement index <0.5); these were used in the clinical scoring system. The rating of clinical scenarios supported the validity of the scoring system. Although there was variability in the interpretation of changes in mast cell tryptase by the panel, we were able to include supplementary scores for mast cell tryptase.ConclusionWe used a robust consensus development process to devise a clinical scoring system for suspected perioperative immediate hypersensitivity reactions. This will enable objectivity and uniformity in the assessment of the sensitivity of diagnostic tests.Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

15 keywords...

hide…