• J. Neurol. Neurosurg. Psychiatr. · Nov 2003

    Case Reports

    Awakenings from persistent vegetative state: report of three cases with parkinsonism and brain stem lesions on MRI.

    • W Matsuda, A Matsumura, Y Komatsu, K Yanaka, and T Nose.
    • Department of Neurosurgery, Tsukuba Medical Centre Hospital, Ibaraki, Japan. wako@mua.biglobe.ne.jp
    • J. Neurol. Neurosurg. Psychiatr. 2003 Nov 1; 74 (11): 1571-3.

    AbstractThree patients with a persistent vegetative state after severe head injury are reported. They recovered from a prolonged disturbance of consciousness after the administration of levodopa. These patients all had parkinsonian features. On magnetic resonance imaging, the distribution of lesions implied a diffuse axonal injury involving the substantia nigra or ventral tegmental area. The existence of patients whose dopaminergic systems may have been selectively damaged by a severe head injury should be recognised because such individuals may respond to levodopa treatment.

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