• J. Neurol. Neurosurg. Psychiatr. · Mar 2004

    Review

    Cerebral perfusion and stroke.

    • H S Markus.
    • Clinical Neuroscience, St George's Hospital Medical School, London, UK. h.markus@sghms.ac.uk
    • J. Neurol. Neurosurg. Psychiatr. 2004 Mar 1; 75 (3): 353-61.

    AbstractStroke is a heterogeneous syndrome caused by multiple disease mechanisms, but all result in a disruption of cerebral blood flow with subsequent tissue damage. This review covers the mechanisms responsible for regulation of the normal cerebral circulation, and how they are disrupted in disease states. A central concept in treating patients with acute ischaemic stroke is the existence of an ischaemic penumbra of potentially salvageable tissue, and the evidence for its existence in humans is reviewed.

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