• J. Neurol. Neurosurg. Psychiatr. · Mar 2004

    Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.

    • C Levecque, A Elbaz, J Clavel, J S Vidal, P Amouyel, A Alpérovitch, C Tzourio, and M C Chartier-Harlin.
    • INSERM Unit 508, Institut Pasteur de Lille, Lille, France.
    • J. Neurol. Neurosurg. Psychiatr. 2004 Mar 1; 75 (3): 478-80.

    BackgroundThe Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease.ObjectiveTo test these two genes for their association with Parkinson's disease in a large community based case-control study.ResultsCases (n = 208) were more often homozygotes for the Tau H1 haplotype than controls (n = 483; odds ratio (OR) = 1.71 (95% confidence interval, 1.20 to 2.43); p = 0.003), and the saitohin Q allele was in complete linkage disequilibrium with the H1 haplotype. This association was stronger among cases with Parkinson's disease onset below 65 years (< or =65 years: OR = 2.52 (1.49 to 4.25); p<0.001) than among those with older onset (>65 years: OR = 1.20 (0.73 to 1.98); p<0.47).ConclusionsThe data suggest that there is a functional polymorphism at this locus involved in Parkinson's disease.

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