• J. Neurol. Neurosurg. Psychiatr. · Apr 2004

    Inhibition of ongoing responses in patients with Parkinson's disease.

    • S Gauggel, M Rieger, and T-A Feghoff.
    • Department of Psychology, University of Technology-Chemnitz, Wilhelm-Raabe-Strasse 43, D-09120 Chemnitz, Germany. siegfried.gauggel@phil.tu-chemnitz.de
    • J. Neurol. Neurosurg. Psychiatr. 2004 Apr 1; 75 (4): 539-44.

    ObjectivesWe investigated the involvement of the basal ganglia in inhibiting ongoing responses in patients with Parkinson's disease (PD).MethodsThirty two patients with PD and 31 orthopaedic controls performed the stop signal task, which allows an estimation of the time it takes to inhibit an ongoing reaction (stop signal reaction time, SSRT).ResultsPatients with PD showed significantly longer SSRTs than the controls. This effect seemed to be independent of global cognitive impairment and severity of PD. Furthermore, in the PD patients, there was no significant relation between general slowing and inhibitory efficiency.ConclusionsOur results provide evidence for involvement of the basal ganglia in the inhibition of ongoing responses.

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