• J Clin Pharm Ther · Feb 2019

    Case Reports

    Lemierre's syndrome: One rare disease-Two case studies.

    • Christine Le, Dean Gennaro, Derek Marshall, Orly Alaev, Alicia Bryan, Aleksandra Gelfman, and Zhe Wang.
    • Touro College of Pharmacy, New York, New York.
    • J Clin Pharm Ther. 2019 Feb 1; 44 (1): 122-124.

    What Is Known And ObjectiveLemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole.Case DescriptionWe present two cases of Lemierre's syndrome with internal jugular vein thrombophlebitis and positive blood cultures for F. necrophorum. The first case was successfully treated with 6 weeks of a beta-lactam antibiotic and 4 weeks of metronidazole, while the second case was successfully treated with 4 weeks of a beta-lactam antibiotic and 2 weeks of metronidazole.What Is New And ConclusionTwo cases of Lemierre's syndrome were treated successfully with only 2-4 weeks of metronidazole therapy. Shorter duration of metronidazole therapy should be explored in future studies.© 2018 John Wiley & Sons Ltd.

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