• Alexandre Challine, Claire Rives-Lange, Divya Danoussou, Sandrine Katsahian, Amel Ait Boudaoud, Sébastien Gaujoux, Bertrand Dousset, Claire Carette, Andrea Lazzati, and Sébastien Czernichow.
• Assistance Publique - Hôpitaux de Paris, Hôpital européen Georges-Pompidou, Service de nutrition, Centre Spécialisé Obésité France, France.
• Ann. Surg. 2021 Apr 1; 273 (4): 725731725-731.

ObjectiveThe objective of the present study was to assess the effect of preoperative immunonutrition on a nationwide scale.BackgroundAccording to international guidelines, immunonutrition should be prescribed before major oncologic digestive surgery to decrease postoperative morbidity. Nevertheless, this practice remains controversial.MethodsWe used a prospective national health database named "Echantillon généraliste des Bénéficiaires." Patients were selected with ICD10 codes of cancer and digestive surgery procedures from 2012 to 2016. Two groups were identified: with reimbursement of immunonutrition 45 days before surgery (IN-group) or not (no-IN-group). Primary outcome was 90-day severe morbidity. Secondary outcomes were postoperative length of stay (LOS) and overall survival. Logistic regression and survival analysis adjusted with IPW method were performed.ResultsOne thousand seven hundred seventy-one patients were included. The proportion of different cancers was as follows: 72% patients were included in the colorectal group, 14% in the hepato-pancreato-biliary group, and 12% in the upper gastrointestinal group. Patients from the IN-group (n = 606, 34%) were younger (67.1 ± 11.8 vs 69.2 ± 12.2 years, P < 0.001), with increased use of other oral nutritional supplements (49.5% vs 31.8%, P < 0.001) and had more digestive anastomoses (89.4% vs 83.0%, P < 0.001). There was no significant difference between the 2 groups for 90-day severe morbidity [odds ratio (OR): 0.91, 95% confidence interval (95% CI): 0.73-1.14] or in survival (hazard ratio: 0.89, 95% CI: 0.73-1.08). LOS were shorter in the IN-group [-1.26 days, 95% CI: -2.40 to -0.10)].ConclusionThe preoperative use of immunonutrition before major oncologic digestive surgery was not associated with any significant difference in morbidity or mortality. However, the LOS was significantly shorter in the IN-group.Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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