• Soheila Rezapour-Firouzi, Seyed Rafie Arefhosseini, Farhoudi Mehdi, Ebrahimi-Mamaghani Mehrangiz, Behzad Baradaran, Elyar Sadeghihokmabad, Somaiyeh Mostafaei, Seyed Mohammad Bagher Fazljou, Mohammad-ali Torbati, Sarvin Sanaie, and Fatemeh Zamani.
• Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; School of Nutrition and Health, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: s.rfirozi@gmail.com.
• Complement Ther Med. 2013 Oct 1; 21 (5): 473-80.

BackgroundMultiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients.Methods And MaterialsIn this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, "Group B" who received olive oil, "Group C" who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-γ and IL-17) were assessed at baseline and after 6 months.ResultsMean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention.ConclusionThe co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings.Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

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